Research services

Biomedical research services for industry, research institutes and individual research groups

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Department of medical chemistry and biochemistry (DMCB) provides screening of a biologically active substance/extract/phytopreparation (on model reactions, mammalian cells and animal models) and consulting services for pharmaceutical and food industry, research institutes and individual research groups.

Based on the needs of the customer, services supplied by DMCB may range from single measurements to complete studies. Assays may be set up according to the requirements of the client. If necessary, we also assist in preparation of the material for publication of results.

The competence of DMCB is achieved and maintained by their active research. At present, research and development activities at DMCB are focused on oxidative stress and antioxidant functions.

We can assist our clients e.g. to investigate effects of plant extracts, phytochemicals, functional food and dietary supplements, on oxidation of LDL (® atherosclerosis) or DNA (® cancer), on cellular defence functions, and to explore antioxidant effects of intact plant/extract/ component/dietary supplement.

Examples of available cell systems:
Rat Hepatocytes Laboratoř buněčných kultur lékařské fakulty
Human Hepatocytes Laboratoř buněčných kultur lékařské fakulty
Rat Neonatal Cardiomyocytes Laboratoř buněčných kultur lékařské fakulty
Human Umbilical Vein Endothelial Cells – HUVEC Laboratoř buněčných kultur lékařské fakulty
Human Keratinocytes Laboratoř buněčných kultur lékařské fakulty
Human Fibroblasts Laboratoř buněčných kultur lékařské fakulty
Human Osteoblasts Laboratoř buněčných kultur lékařské fakulty
Research activities of DMCB:

1.   Antioxidant testing

2.   Lipid metabolism

3.   Cellular defence functions

4.   DNA damage

5.  Effects on cytochrome P450 system

6.  Cell cytotoxicity/cytoprotectivity

7. Safety evaluation on experimental animals

8. Safety evaluation on human volunteers

Contact:

Prof. RNDr. Jitka Ulrichová, CSc.
Department of Medical Chemistry and Biochemistry (DMCB)
Hněvotínská 3, 775 15 Olomouc
Czech Republic

Tel/Fax    +420 585 632 312
E-mail   jitkaulrichova@seznam.cz